| Schedule for Week #1 |
| Matchup | Time | Visitor | | Spread | Home Team | |
| Thursday, September 09 2021 |
| Matchup | 5:20 PM | (105) Dallas Cowboys | | +7 1/2 | (449) Tampa Bay Bucs | | 29-31 | Final |
| Sunday, September 12 2021 |
| Matchup | 10 AM | (142) Philadelphia Eagles | | +3 1/2 | (194) Atlanta Falcons | | 32-6 | Final |
| Matchup | 10 AM | (133) Pittsburgh Steelers | | +6 1/2 | (318) Buffalo Bills | | 23-16 | Final |
| Matchup | 10 AM | (102) New York Jets | | +5 | (285) Carolina Panthers | | 14-19 | Final |
| Matchup | 10 AM | (354) Minnesota Vikings | | -3 | (27) Cincinnati Bengals | | 24-27 | Final |
| Matchup | 10 AM | (670) San Francisco 49ers | | -7 1/2 | (35) Detroit Lions | | 41-33 | Final |
| Matchup | 10 AM | (181) Jacksonville Jaguars | | -3 | (82) Houston Texans | | 21-37 | Final |
| Matchup | 10 AM | (542) Seattle Seahawks | | -2 1/2 | (94) Indianapolis Colts | | 28-16 | Final |
| Matchup | 10 AM | (96) Arizona Cardinals | | +3 | (308) Tennessee Titans | | 38-13 | Final |
| Matchup | 10 AM | (336) Los Angeles Chargers | | -1 | (198) Washington Redskins | | 20-16 | Final |
| Matchup | 1:25 PM | (116) Cleveland Browns | | +6 | (533) Kansas City Chiefs | | 29-33 | Final |
| Matchup | 1:25 PM | (122) Miami Dolphins | | +3 | (174) New England Patriots | | 17-16 | Final |
| Matchup | 1:25 PM | (643) Green Bay Packers | | -4 | (46) New Orleans Saints | | 3-38 | Final |
| Matchup | 1:25 PM | (375) Denver Broncos | | -2 1/2 | (65) New York Giants | | 27-13 | Final |
| Matchup | 5:20 PM | (105) Chicago Bears | | +7 1/2 | (380) Los Angeles Rams | | 14-34 | Final |
| Monday, September 13 2021 |
| Matchup | 5:15 PM | (321) Baltimore Ravens | | -4 1/2 | (169) Las Vegas Raiders | | 27-33 | Final |
| ( ) Total points by all players | |
| This Weeks Deadlines |
| Game Day | Picks Due By |
| Thursday, September 09 2021 | Thursday @ 04:20 PM |
| Sunday, September 12 2021 | Saturday @ 10:00 PM |
| Monday, September 13 2021 | Saturday @ 10:00 PM |