| Schedule for Week #12 |
| Matchup | Time | Visitor | | Spread | Home Team | |
| Thursday, November 25 2021 |
| Matchup | 9:30 AM | (273) Chicago Bears | | -3 1/2 | (179) Detroit Lions | | 16-14 | Final |
| Matchup | 1:30 PM | (196) Las Vegas Raiders | | +8 | (322) Dallas Cowboys | | 36-33 | Final |
| Matchup | 5:20 PM | (521) Buffalo Bills | | -4 1/2 | (72) New Orleans Saints | | 31-6 | Final |
| Sunday, November 28 2021 |
| Matchup | 10 AM | (378) Pittsburgh Steelers | | +4 1/2 | (181) Cincinnati Bengals | | 10-41 | Final |
| Matchup | 10 AM | (143) New York Jets | | +3 | (230) Houston Texans | | 21-14 | Final |
| Matchup | 10 AM | (541) Tampa Bay Bucs | | -2 1/2 | (174) Indianapolis Colts | | 38-31 | Final |
| Matchup | 10 AM | (264) Atlanta Falcons | | -1 | (71) Jacksonville Jaguars | | 21-14 | Final |
| Matchup | 10 AM | (362) Carolina Panthers | | -2 | (86) Miami Dolphins | | 10-33 | Final |
| Matchup | 10 AM | (304) Tennessee Titans | | +6 1/2 | (263) New England Patriots | | 13-36 | Final |
| Matchup | 10 AM | (536) Philadelphia Eagles | | -3 1/2 | (62) New York Giants | | 7-13 | Final |
| Matchup | 1:05 PM | (495) Los Angeles Chargers | | -2 1/2 | (93) Denver Broncos | | 13-28 | Final |
| Matchup | 1:25 PM | (229) Los Angeles Rams | | +1 | (273) Green Bay Packers | | 28-36 | Final |
| Matchup | 1:25 PM | (241) Minnesota Vikings | | +3 | (276) San Francisco 49ers | | 26-34 | Final |
| Matchup | 5:20 PM | (103) Cleveland Browns | | +4 | (327) Baltimore Ravens | | 10-16 | Final |
| Monday, November 29 2021 |
| Matchup | 5:15 PM | (226) Seattle Seahawks | | +1 | (169) Washington Redskins | | 15-17 | Final |
| ( ) Total points by all players | |
| This Weeks Deadlines |
| Game Day | Picks Due By |
| Thursday, November 25 2021 | Thursday @ 08:30 AM |
| Sunday, November 28 2021 | Saturday @ 10:00 PM |
| Monday, November 29 2021 | Saturday @ 10:00 PM |