| Schedule for Week #11 |
| Matchup | Time | Visitor | | Spread | Home Team | |
| Thursday, November 18 2021 |
| Matchup | 5:20 PM | (454) New England Patriots | | -6 1/2 | (56) Atlanta Falcons | | 25-0 | Final |
| Sunday, November 21 2021 |
| Matchup | 10 AM | (206) Indianapolis Colts | | +7 | (369) Buffalo Bills | | 41-15 | Final |
| Matchup | 10 AM | (74) Washington Redskins | | +3 | (346) Carolina Panthers | | 27-21 | Final |
| Matchup | 10 AM | (430) Baltimore Ravens | | -6 1/2 | (117) Chicago Bears | | 16-13 | Final |
| Matchup | 10 AM | (141) Detroit Lions | | +9 1/2 | (304) Cleveland Browns | | 10-13 | Final |
| Matchup | 10 AM | (545) San Francisco 49ers | | -5 1/2 | (91) Jacksonville Jaguars | | 30-10 | Final |
| Matchup | 10 AM | (616) Green Bay Packers | | -2 1/2 | (201) Minnesota Vikings | | 31-34 | Final |
| Matchup | 10 AM | (408) Miami Dolphins | | -3 | (48) New York Jets | | 24-17 | Final |
| Matchup | 10 AM | (264) New Orleans Saints | | +1 1/2 | (192) Philadelphia Eagles | | 29-40 | Final |
| Matchup | 10 AM | (116) Houston Texans | | +10 1/2 | (354) Tennessee Titans | | 22-13 | Final |
| Matchup | 1:05 PM | (256) Cincinnati Bengals | | -1 | (195) Las Vegas Raiders | | 32-13 | Final |
| Matchup | 1:25 PM | (333) Dallas Cowboys | | +2 1/2 | (237) Kansas City Chiefs | | 9-19 | Final |
| Matchup | 1:25 PM | (265) Arizona Cardinals | | -2 1/2 | (262) Seattle Seahawks | | 23-13 | Final |
| Matchup | 5:20 PM | (145) Pittsburgh Steelers | | +4 1/2 | (333) Los Angeles Chargers | | 37-41 | Final |
| Monday, November 22 2021 |
| Matchup | 5:15 PM | (152) New York Giants | | +11 | (300) Tampa Bay Bucs | | 10-30 | Final |
| ( ) Total points by all players | |
| This Weeks Deadlines |
| Game Day | Picks Due By |
| Thursday, November 18 2021 | Thursday @ 04:20 PM |
| Sunday, November 21 2021 | Saturday @ 10:00 PM |
| Monday, November 22 2021 | Saturday @ 10:00 PM |