| Schedule for Week #17 |
| Matchup | Time | Visitor | | Spread | Home Team | |
| Sunday, January 02 2022 |
| Matchup | 10 AM | (157) Atlanta Falcons | | +14 1/2 | (174) Buffalo Bills | | 15-29 | Final |
| Matchup | 10 AM | (113) New York Giants | | +6 | (171) Chicago Bears | | 3-29 | Final |
| Matchup | 10 AM | (349) Kansas City Chiefs | | -5 | (200) Cincinnati Bengals | | 31-34 | Final |
| Matchup | 10 AM | (202) Arizona Cardinals | | +5 1/2 | (354) Dallas Cowboys | | 25-22 | Final |
| Matchup | 10 AM | (244) Las Vegas Raiders | | +7 1/2 | (243) Indianapolis Colts | | 23-20 | Final |
| Matchup | 10 AM | (68) Jacksonville Jaguars | | +15 1/2 | (217) New England Patriots | | 10-50 | Final |
| Matchup | 10 AM | (126) Carolina Panthers | | +7 1/2 | (148) New Orleans Saints | | 10-18 | Final |
| Matchup | 10 AM | (385) Tampa Bay Bucs | | -13 | (52) New York Jets | | 28-24 | Final |
| Matchup | 10 AM | (128) Miami Dolphins | | +3 | (352) Tennessee Titans | | 3-34 | Final |
| Matchup | 10 AM | (466) Philadelphia Eagles | | -3 1/2 | (48) Washington Redskins | | 20-16 | Final |
| Matchup | 1:05 PM | (82) Denver Broncos | | +5 1/2 | (435) Los Angeles Chargers | | 13-34 | Final |
| Matchup | 1:05 PM | (158) Houston Texans | | +13 | (130) San Francisco 49ers | | 7-23 | Final |
| Matchup | 1:25 PM | (596) Los Angeles Rams | | -3 1/2 | (68) Baltimore Ravens | | 20-19 | Final |
| Matchup | 1:25 PM | (138) Detroit Lions | | +6 1/2 | (242) Seattle Seahawks | | 29-51 | Final |
| Matchup | 5:20 PM | (84) Minnesota Vikings | | +6 1/2 | (694) Green Bay Packers | | 10-37 | Final |
| Monday, January 03 2022 |
| Matchup | 5:15 PM | (189) Cleveland Browns | | -3 | (137) Pittsburgh Steelers | | 14-26 | Final |
| ( ) Total points by all players | |