| Schedule for Week #6 |
| Matchup | Time | Visitor | | Spread | Home Team | |
| Thursday, October 14 2021 |
| Matchup | 5:20 PM | (347) Tampa Bay Bucs | | -7 | (54) Philadelphia Eagles | | 28-22 | Final |
| Sunday, October 17 2021 |
| Matchup | 6:30 AM | (197) Miami Dolphins | | -3 1/2 | (178) Jacksonville Jaguars | | 20-23 | Final |
| Matchup | 10 AM | (522) Los Angeles Chargers | | +3 1/2 | (101) Baltimore Ravens | | 6-34 | Final |
| Matchup | 10 AM | (232) Minnesota Vikings | | +1 | (186) Carolina Panthers | | 34-28 | Final |
| Matchup | 10 AM | (736) Green Bay Packers | | -4 1/2 | (97) Chicago Bears | | 24-14 | Final |
| Matchup | 10 AM | (447) Cincinnati Bengals | | -3 | (77) Detroit Lions | | 34-11 | Final |
| Matchup | 10 AM | (128) Houston Texans | | +10 | (170) Indianapolis Colts | | 3-31 | Final |
| Matchup | 10 AM | (443) Los Angeles Rams | | -10 1/2 | (85) New York Giants | | 38-11 | Final |
| Matchup | 10 AM | (750) Kansas City Chiefs | | -6 1/2 | (51) Washington Redskins | | 31-13 | Final |
| Matchup | 1:05 PM | (318) Arizona Cardinals | | +2 1/2 | (293) Cleveland Browns | | 37-14 | Final |
| Matchup | 1:25 PM | (172) Las Vegas Raiders | | +3 1/2 | (246) Denver Broncos | | 34-24 | Final |
| Matchup | 1:25 PM | (666) Dallas Cowboys | | -4 | (130) New England Patriots | | 35-29 | Final |
| Matchup | 5:20 PM | (195) Seattle Seahawks | | +5 | (314) Pittsburgh Steelers | | 20-23 | Final |
| Monday, October 18 2021 |
| Matchup | 5:15 PM | (610) Buffalo Bills | | -5 1/2 | (120) Tennessee Titans | | 31-34 | Final |
| ( ) Total points by all players | |
| This Weeks Deadlines |
| Game Day | Picks Due By |
| Thursday, October 14 2021 | Thursday @ 04:20 PM |
| Sunday, October 17 2021 | Saturday @ 10:00 PM |
| Monday, October 18 2021 | Saturday @ 10:00 PM |