| Schedule for Week #4 |
| Matchup | Time | Visitor | | Spread | Home Team | |
| Thursday, September 30 2021 |
| Matchup | 5:20 PM | (67) Jacksonville Jaguars | | +7 1/2 | (321) Cincinnati Bengals | | 21-24 | Final |
| Sunday, October 03 2021 |
| Matchup | 10 AM | (109) Washington Redskins | | -1 1/2 | (142) Atlanta Falcons | | 34-30 | Final |
| Matchup | 10 AM | (62) Houston Texans | | +16 1/2 | (202) Buffalo Bills | | 0-40 | Final |
| Matchup | 10 AM | (174) Detroit Lions | | +3 | (95) Chicago Bears | | 14-24 | Final |
| Matchup | 10 AM | (175) Carolina Panthers | | +4 | (403) Dallas Cowboys | | 28-36 | Final |
| Matchup | 10 AM | (156) Indianapolis Colts | | +1 1/2 | (184) Miami Dolphins | | 27-17 | Final |
| Matchup | 10 AM | (339) Cleveland Browns | | -2 | (179) Minnesota Vikings | | 14-7 | Final |
| Matchup | 10 AM | (172) New York Giants | | +7 1/2 | (351) New Orleans Saints | | 27-21 | Final |
| Matchup | 10 AM | (625) Tennessee Titans | | -7 1/2 | (97) New York Jets | | 24-27 | Final |
| Matchup | 10 AM | (793) Kansas City Chiefs | | -6 1/2 | (26) Philadelphia Eagles | | 42-30 | Final |
| Matchup | 1:05 PM | (190) Arizona Cardinals | | +6 | (289) Los Angeles Rams | | 37-20 | Final |
| Matchup | 1:05 PM | (234) Seattle Seahawks | | +3 | (216) San Francisco 49ers | | 28-21 | Final |
| Matchup | 1:25 PM | (350) Baltimore Ravens | | +1 1/2 | (171) Denver Broncos | | 23-7 | Final |
| Matchup | 1:25 PM | (91) Pittsburgh Steelers | | +6 1/2 | (511) Green Bay Packers | | 17-27 | Final |
| Matchup | 5:20 PM | (697) Tampa Bay Bucs | | -6 1/2 | (45) New England Patriots | | 19-17 | Final |
| Monday, October 04 2021 |
| Matchup | 5:15 PM | (247) Las Vegas Raiders | | +3 1/2 | (207) Los Angeles Chargers | | 14-28 | Final |
| ( ) Total points by all players | |
| This Weeks Deadlines |
| Game Day | Picks Due By |
| Thursday, September 30 2021 | Thursday @ 04:20 PM |
| Sunday, October 03 2021 | Saturday @ 10:00 PM |
| Monday, October 04 2021 | Saturday @ 10:00 PM |