| Schedule for Week #5 |
| Matchup | Time | Visitor | | Spread | Home Team | |
| Thursday, October 07 2021 |
| Matchup | 5:20 PM | (358) Los Angeles Rams | | -1 1/2 | (101) Seattle Seahawks | | 26-17 | Final |
| Sunday, October 10 2021 |
| Matchup | 6:30 AM | (131) New York Jets | | +3 1/2 | (214) Atlanta Falcons | | 20-27 | Final |
| Matchup | 10 AM | (135) Philadelphia Eagles | | +4 | (306) Carolina Panthers | | 21-18 | Final |
| Matchup | 10 AM | (589) Green Bay Packers | | -3 1/2 | (129) Cincinnati Bengals | | 25-22 | Final |
| Matchup | 10 AM | (250) New England Patriots | | -9 | (77) Houston Texans | | 25-22 | Final |
| Matchup | 10 AM | (475) Tennessee Titans | | -4 | (33) Jacksonville Jaguars | | 37-19 | Final |
| Matchup | 10 AM | (103) Detroit Lions | | +7 1/2 | (336) Minnesota Vikings | | 17-19 | Final |
| Matchup | 10 AM | (161) Denver Broncos | | +1 | (216) Pittsburgh Steelers | | 19-27 | Final |
| Matchup | 10 AM | (149) Miami Dolphins | | +10 | (316) Tampa Bay Bucs | | 17-45 | Final |
| Matchup | 10 AM | (294) New Orleans Saints | | -1 1/2 | (112) Washington Redskins | | 33-22 | Final |
| Matchup | 1:05 PM | (82) Cleveland Browns | | Even | (484) Los Angeles Chargers | | 42-47 | Final |
| Matchup | 1:05 PM | (105) Chicago Bears | | +4 1/2 | (473) Las Vegas Raiders | | 20-9 | Final |
| Matchup | 1:25 PM | (256) San Francisco 49ers | | +5 1/2 | (433) Arizona Cardinals | | 10-17 | Final |
| Matchup | 1:25 PM | (90) New York Giants | | +7 | (470) Dallas Cowboys | | 20-44 | Final |
| Matchup | 5:20 PM | (298) Buffalo Bills | | +2 1/2 | (264) Kansas City Chiefs | | 38-20 | Final |
| Monday, October 11 2021 |
| Matchup | 5:15 PM | (62) Indianapolis Colts | | +7 | (363) Baltimore Ravens | | 25-31 | Final |
| ( ) Total points by all players | |
| This Weeks Deadlines |
| Game Day | Picks Due By |
| Thursday, October 07 2021 | Thursday @ 04:20 PM |
| Sunday, October 10 2021 | Saturday @ 10:00 PM |
| Monday, October 11 2021 | Saturday @ 10:00 PM |