| Schedule for Week #10 |
| Matchup | Time | Visitor | | Spread | Home Team | |
| Thursday, November 11 2021 |
| Matchup | 5:20 PM | (526) Baltimore Ravens | | -7 1/2 | (53) Miami Dolphins | | 10-22 | Final |
| Sunday, November 14 2021 |
| Matchup | 10 AM | (240) Atlanta Falcons | | +9 | (296) Dallas Cowboys | | 3-43 | Final |
| Matchup | 10 AM | (129) Jacksonville Jaguars | | +10 1/2 | (230) Indianapolis Colts | | 17-23 | Final |
| Matchup | 10 AM | (269) Cleveland Browns | | +1 1/2 | (344) New England Patriots | | 7-45 | Final |
| Matchup | 10 AM | (351) Buffalo Bills | | -13 | (71) New York Jets | | 45-17 | Final |
| Matchup | 10 AM | (216) Detroit Lions | | +9 | (182) Pittsburgh Steelers | | 16-16 | Final |
| Matchup | 10 AM | (145) New Orleans Saints | | +3 | (511) Tennessee Titans | | 21-23 | Final |
| Matchup | 10 AM | (551) Tampa Bay Bucs | | -9 1/2 | (86) Washington Redskins | | 19-29 | Final |
| Matchup | 1:05 PM | (105) Carolina Panthers | | +10 | (286) Arizona Cardinals | | 34-10 | Final |
| Matchup | 1:05 PM | (144) Minnesota Vikings | | +2 1/2 | (618) Los Angeles Chargers | | 27-20 | Final |
| Matchup | 1:25 PM | (130) Philadelphia Eagles | | +2 1/2 | (377) Denver Broncos | | 30-13 | Final |
| Matchup | 1:25 PM | (164) Seattle Seahawks | | +4 | (353) Green Bay Packers | | 0-17 | Final |
| Matchup | 5:20 PM | (406) Kansas City Chiefs | | -2 1/2 | (263) Las Vegas Raiders | | 41-14 | Final |
| Monday, November 15 2021 |
| Matchup | 5:15 PM | (698) Los Angeles Rams | | -4 | (66) San Francisco 49ers | | 10-31 | Final |
| ( ) Total points by all players | |
| This Weeks Deadlines |
| Game Day | Picks Due By |
| Thursday, November 11 2021 | Thursday @ 04:20 PM |
| Sunday, November 14 2021 | Saturday @ 10:00 PM |
| Monday, November 15 2021 | Saturday @ 10:00 PM |