| Schedule for Week #2 |
| Matchup | Time | Visitor | | Spread | Home Team | |
| Thursday, September 16 2021 |
| Matchup | 5:20 PM | (65) New York Giants | | +3 1/2 | (245) Washington Redskins | | 29-30 | Final |
| Sunday, September 19 2021 |
| Matchup | 10 AM | (506) New Orleans Saints | | -3 1/2 | (160) Carolina Panthers | | 7-26 | Final |
| Matchup | 10 AM | (185) Cincinnati Bengals | | +3 | (168) Chicago Bears | | 17-20 | Final |
| Matchup | 10 AM | (185) Houston Texans | | +12 1/2 | (152) Cleveland Browns | | 21-31 | Final |
| Matchup | 10 AM | (678) Los Angeles Rams | | -4 | (59) Indianapolis Colts | | 27-24 | Final |
| Matchup | 10 AM | (366) Denver Broncos | | -6 | (52) Jacksonville Jaguars | | 23-13 | Final |
| Matchup | 10 AM | (472) Buffalo Bills | | -3 1/2 | (83) Miami Dolphins | | 35-0 | Final |
| Matchup | 10 AM | (397) New England Patriots | | -5 1/2 | (25) New York Jets | | 25-6 | Final |
| Matchup | 10 AM | (385) San Francisco 49ers | | -3 1/2 | (211) Philadelphia Eagles | | 17-11 | Final |
| Matchup | 10 AM | (171) Las Vegas Raiders | | +6 | (258) Pittsburgh Steelers | | 26-17 | Final |
| Matchup | 1:05 PM | (117) Minnesota Vikings | | +4 | (459) Arizona Cardinals | | 33-34 | Final |
| Matchup | 1:05 PM | (90) Atlanta Falcons | | +13 | (214) Tampa Bay Bucs | | 25-48 | Final |
| Matchup | 1:25 PM | (266) Dallas Cowboys | | +3 | (269) Los Angeles Chargers | | 20-17 | Final |
| Matchup | 1:25 PM | (137) Tennessee Titans | | +5 1/2 | (350) Seattle Seahawks | | 33-30 | Final |
| Matchup | 5:20 PM | (589) Kansas City Chiefs | | -3 | (45) Baltimore Ravens | | 35-36 | Final |
| Monday, September 20 2021 |
| Matchup | 5:15 PM | (123) Detroit Lions | | +10 1/2 | (273) Green Bay Packers | | 17-35 | Final |
| ( ) Total points by all players | |
| This Weeks Deadlines |
| Game Day | Picks Due By |
| Thursday, September 16 2021 | Thursday @ 04:20 PM |
| Sunday, September 19 2021 | Saturday @ 10:00 PM |
| Monday, September 20 2021 | Saturday @ 10:00 PM |