| Schedule for Week #3 |
| Matchup | Time | Visitor | | Spread | Home Team | |
| Thursday, September 23 2021 |
| Matchup | 5:20 PM | (416) Carolina Panthers | | -7 1/2 | (70) Houston Texans | | 24-9 | Final |
| Sunday, September 26 2021 |
| Matchup | 10 AM | (169) Washington Redskins | | +9 | (275) Buffalo Bills | | 21-43 | Final |
| Matchup | 10 AM | (118) Chicago Bears | | +7 1/2 | (371) Cleveland Browns | | 6-26 | Final |
| Matchup | 10 AM | (296) Baltimore Ravens | | -9 | (111) Detroit Lions | | 19-17 | Final |
| Matchup | 10 AM | (581) Arizona Cardinals | | -7 | (41) Jacksonville Jaguars | | 31-19 | Final |
| Matchup | 10 AM | (169) Los Angeles Chargers | | +6 1/2 | (460) Kansas City Chiefs | | 30-24 | Final |
| Matchup | 10 AM | (138) New Orleans Saints | | +3 | (230) New England Patriots | | 28-13 | Final |
| Matchup | 10 AM | (95) Atlanta Falcons | | +3 | (118) New York Giants | | 17-14 | Final |
| Matchup | 10 AM | (175) Cincinnati Bengals | | +4 1/2 | (262) Pittsburgh Steelers | | 24-10 | Final |
| Matchup | 10 AM | (133) Indianapolis Colts | | +5 1/2 | (354) Tennessee Titans | | 16-25 | Final |
| Matchup | 1:05 PM | (78) New York Jets | | +11 | (321) Denver Broncos | | 0-26 | Final |
| Matchup | 1:05 PM | (87) Miami Dolphins | | +4 | (706) Las Vegas Raiders | | 28-31 | Final |
| Matchup | 1:25 PM | (388) Tampa Bay Bucs | | +1 | (170) Los Angeles Rams | | 24-34 | Final |
| Matchup | 1:25 PM | (494) Seattle Seahawks | | -1 1/2 | (94) Minnesota Vikings | | 17-30 | Final |
| Matchup | 5:20 PM | (314) Green Bay Packers | | +4 | (177) San Francisco 49ers | | 30-28 | Final |
| Monday, September 27 2021 |
| Matchup | 5:15 PM | (94) Philadelphia Eagles | | +4 | (360) Dallas Cowboys | | 21-41 | Final |
| ( ) Total points by all players | |
| This Weeks Deadlines |
| Game Day | Picks Due By |
| Thursday, September 23 2021 | Thursday @ 04:20 PM |
| Sunday, September 26 2021 | Saturday @ 10:00 PM |
| Monday, September 27 2021 | Saturday @ 10:00 PM |